marked

a marked lack of enthusiasm

明显缺乏热情

The patient showed a marked improvement in her condition after changing medication.

换药治疗后病人的病情明显好转。

Miller’s organized desk stood in marked contrast to the rest of the office.

米勒的桌子上整理得井井有条，和办公室里的其他桌子形成明显的对比。